Adolescent MDMA exposure diminishes the physiological and neurotoxic consequences of an MDMA binge in female rats
Developmental Psychobiology July 1, 2014 Brian J. Piper, Christina S. Henderson, Jerrold S. Meyer 2 citations
In female rats, prior intermittent exposure to MDMA (ecstasy) prevented the drop in serotonin transporter binding and the body temperature disruption normally caused by a later high-dose MDMA binge. Unlike males, female rats did not show reduced motor activity after the binge. The findings indicate that while females and males respond differently to an MDMA binge, both sexes exhibit a preconditioning effect from earlier MDMA exposure that protects against some of the binge's harmful effects.