Critical review of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for posttraumatic stress disorder: Unanswered questions and future directions
Journal of Psychedelic Studies July 18, 2024 Alex P. Hood, Chris E. Corlett, Cameron T. Alldredge et al. 1 citation
A critical review of six randomized controlled trials of MDMA-assisted therapy for PTSD finds that five show evidence of safety and efficacy. However, the review identifies serious methodological problems: lack of a suitable comparison condition, poor blinding, rigid trial designs, high treatment costs, and no head-to-head comparisons with established PTSD therapies. The sponsoring organization behind all trials may introduce bias. While the results are encouraging, there is not yet enough evidence to recommend widespread adoption of MDMA-assisted therapy over current validated treatments.