MDMA-assisted therapy is associated with a reduction in chronic pain among people with post-traumatic stress disorder
Frontiers in Psychiatry November 3, 2022 Devon Christie, Berra Yazar-Klosinski, Ekaterina Nosova et al. 8 citations
Chronic pain and post-traumatic stress disorder (PTSD) frequently co-occur and worsen each other. In a Phase 2 open-label trial of MDMA-assisted therapy for PTSD, 84% of 32 participants reported pain and 75% reported pain-related disability. After treatment, those with the highest baseline pain showed significant reductions in pain intensity, disability, and overall severity grade; those with medium baseline pain also showed significant reductions in pain intensity. The findings suggest MDMA-assisted therapy may reduce chronic pain in people with severe PTSD, but the data are preliminary and encourage further research.