The Effects of Folic Acid on Testicular Histology, Sperm Quality, and Spermatogenesis Indices Following 3,4-Methylenedioxymethamphetamine Exposure in Adult Male Rats
Addiction and Health September 4, 2023 Iman Rad, Arezoo Saberi, Najmeh Sadat Koochakzadeh-Nematollahi et al. 6 citations
In adult male rats, the drug MDMA (a form of ecstasy) damaged sperm quality, testicular structure, and hormone levels, and disrupted antioxidant enzyme activity. Giving folic acid alongside MDMA partly reversed these harmful effects, bringing the measures closer to those of untreated rats. The findings suggest that folic acid may help protect male reproductive function against MDMA toxicity.