Michael A. Wheeler: Psychedelics and neuroimmune circuits—what a strange trip, indeed
Psychedelics May 6, 2025 Michael A. Wheeler
Psychedelics like psilocybin can reverse stress-induced fear behaviors by targeting a previously hidden neuroimmune pathway connecting inflammatory cells in the meninges to brain regions controlling emotions and rewards. This research, validated in a Nature article, shows that psychedelics regulate the interplay between brain and immune cells in fear responses. By modulating both neurons and immune responses, the work opens new therapeutic possibilities for depression, addiction, and stress-related disorders.