Disrupted integration of sensory stimuli with information about the movement of the body as a mechanism explaining LSD-induced experience.
Medical hypotheses March 1, 2017 Grzegorz R Juszczak 4 citations
LSD, a model psychedelic, triggers sensory experiences such as illusory movement, floating, merging with surroundings, and out-of-body experiences. While the molecular action at 5-HT2a receptors is known, how these lead to specific sensations is unclear. The authors propose that LSD disrupts the integration of sensory input with information about the body's movement, as serotonergic neurons normally convey motor activity and orienting responses. This disruption results in the perception of illusory movement attributed to the self or external objects.