Department of Cyclotron and Radiopharmaceuticals Research, Advanced Radioisotope Production Center, Institute of Nuclear Medicine and Allied Sciences, Brig. SK Mazumdar Road, Timarpur, Delhi, 110054, India.
2 papers in the library · 61 citations · publishing 2018-2025
A potent and selective kappa opioid receptor (KOPr) analogue of Salvinorin A, Mesyl Sal B, reduces cocaine-induced hyperactivity and behavioral sensitization to cocaine in male rats without causing aversion, sedation, anxiety, or learning and memory deficits. It does not alter sucrose self-administration. However, it increases immobility in the forced swim test, indicating pro-depressive effects. In male mice, Mesyl Sal B is less potent than Salvinorin A at reducing pain in antinociceptive assays. The compound has fewer side effects and longer in vivo action than Salvinorin A, but its pain-relieving effects are limited.
Depression impairs cognition, learning, and memory by disrupting brain chemistry. The monoamine hypothesis links depression to low serotonin, dopamine, and norepinephrine. Antidepressants such as SSRIs and SNRIs, which block serotonin and norepinephrine transporters, are primary treatments for major depressive disorder. Recently, psychedelics have gained importance as antidepressants. This review covers SSRIs, SNRIs, and psychedelics, their target receptors, and recent treatment advances. It also discusses the polypharmacology of psychedelics and fMRI studies that illuminate brain dynamics under psychedelics.