Functional effects of synthetic cannabinoids versus Δ9 -THC in mice on body temperature, nociceptive threshold, anxiety, cognition, locomotor/exploratory parameters and depression.
Addiction biology May 1, 2019 Shaul Schreiber, Miaad Bader, Tatiana Lenchinski et al. 30 citations
Three synthetic cannabinoids (AB-FUBINACA, AB-CHMINACA, PB-22) and Δ9-THC all caused hypothermia and reduced anxiety, spatial memory, and exploratory behavior in adult ICR mice. Only Δ9-THC produced clear pain relief. Unlike Δ9-THC, all synthetic cannabinoids decreased locomotor activity. AB-FUBINACA and Δ9-THC impaired balance and grip strength. PB-22 increased depression-like behavior, while AB-FUBINACA reduced it. The findings indicate varied effects among synthetic cannabinoids and Δ9-THC.