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Andrea Pigorini

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via della Commenda 10, 20122 Milan, Italy; UOC Maxillo-facial Surgery and Dentistry, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Via Francesco Sforza 28, 20122 Milan, Italy.

3 papers in the library · 124 citations · publishing 2024-2025

Papers

An integrative, multiscale view on neural theories of consciousness.

Neuron May 15, 2024 Johan F Storm, P Christiaan Klink, Jaan Aru et al. 108 citations

Consciousness may be explained by multiple, partly compatible theories rather than a single winner. A group of scientists representing different theories argue that various accounts often address different aspects or mechanistic levels of conscious experience, so they do not necessarily contradict each other. Instead, several theories may converge on fundamental neuronal mechanisms and be complementary, allowing multiple perspectives to simultaneously advance understanding. The authors advocate for unifying, integration-oriented approaches that combine valuable elements from diverse theories, an approach that has so far been largely neglected.

Conscious tactile perception entails distinct neural dynamics within somatosensory areas.

Current biology : CB June 9, 2025 Davide Albertini, Maria Del Vecchio, Ivana Sartori et al. 9 citations

Conscious perception of simple touch depends on sustained neural activity in higher-order somatosensory regions, specifically the posterior perisylvian areas. Using human intracortical recordings, tonic responses in these regions showed all-or-nothing patterns at the sensory threshold, remained unchanged whether or not participants reported the stimulus, and most clearly distinguished perceived from non-perceived stimuli. These dynamics may serve as an organizational principle of somatosensory awareness.

Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans.

PLoS biology October 1, 2025 Michele Angelo Colombo, Jacopo Favaro, Ezequiel Mikulan et al. 7 citations

After hemispherotomy surgery for epilepsy, which disconnects an entire brain hemisphere, the isolated cortex shows brainwave patterns typical of deep sleep or anesthesia, not wakefulness. In 10 pediatric patients, EEG recordings revealed prominent slow oscillations and a steeper spectral decay in the disconnected hemisphere, while the connected hemisphere maintained normal waking patterns. These sleep-like patterns persisted years after surgery, suggesting the isolated cortex likely lacks awareness.