Dissociative-like Neurotoxicity Following Analytically Confirmed Exposure To Hexahydrocannabinol (HHC).
Journal of medical toxicology : official journal of the American College of Medical Toxicology January 1, 2026 Shaun L Greene, Rebecca Fawcett, Jared Castle et al. 1 citation
A 32-year-old man experienced multi-system toxicity after eating a single gummy sold as a THC product, which actually contained hexahydrocannabinol (HHC), a semi-synthetic cannabinoid. Within 1.5 hours he developed nausea, vomiting, slurred speech, whole-body numbness, inability to move his head, a dissociative state, rapid heart rate (118 bpm), dilated pupils, confusion, and rapid breathing (24 breaths per minute). No other drugs were detected. Symptoms resolved within eight hours with supportive care. HHC can be manufactured from cannabidiol and is rapidly absorbed, crosses the blood-brain barrier, and is metabolized in the liver. This case highlights the dangers of unregulated cannabis products.