Naltrexone in the Treatment of Ketamine Use Disorders: A Case Report and Literature Review.
Journal of addiction medicine October 2, 2025 Rishi Verma, Tom Colley, Claire Waldock et al. 1 citation
A 25-year-old woman with ketamine use disorder (KUD) who used ketamine daily and experienced intense cravings was prescribed naltrexone off-label, starting at 25 mg/day and increasing to 50 mg/day after 7 days. After starting naltrexone, she reported a marked reduction in cravings, maintained abstinence, and progressed in recovery. This case, consistent with two prior reports where 50 mg/day naltrexone helped patients achieve abstinence, suggests naltrexone may be an effective intervention for KUD. Larger double-blind studies are needed to evaluate its efficacy, safety, and optimal dosing.