Δ9-Tetrahydrocannabinol Alters Limbic and Frontal Functional Brain Connectomes Among Young Adult Cannabis Users.
Biological psychiatry. Cognitive neuroscience and neuroimaging May 1, 2026 Zachary Anderson, Matthew Gunn, Emily Jones et al.
A moderate oral dose of THC (7.5 mg) reduced resting-state functional connectivity within several brain networks, including corticostriatal circuits and networks involved in sensory processing, interoception, and spatial reasoning, in 33 healthy occasional young adult cannabis users. THC also decreased connectivity between two specific networks: one involving the anterior cingulate cortex and dorsal insula, and another involving the ventral insula and lingual gyrus. These connectivity changes were not related to subjective drug effects or recent cannabis use. The findings indicate that even a single moderate THC dose broadly disrupts intrinsic brain network connectivity.