Altered excitation-inhibition balance in the somatomotor and default mode network in multiple sclerosis
medRxiv Preprint Server January 14, 2026 Gaia Zin, Guy Nagels, Jeroen Van Schependom et al. preprint
Disruption of the balance between excitatory and inhibitory neural processes is thought to play a role in multiple sclerosis (MS), but no fMRI-based method has been available to measure this balance in MS. This paper introduces a novel fMRI technique for assessing E/I balance in people with MS, addressing a gap left by traditional electrophysiological measures.