Effects on homeostasis of 5-hydroxytryptamine, lysergic acid diethylamide and 2-brom-d-lysergic acid
American Journal of Physiology-Legacy Content December 1, 1959 J. Paul Mcneill, John K. Hampton 3 citations
In rats, the effect of serotonin (5-HT) and LSD on mortality after physical trauma depends on the route of administration. Intramuscular injection of 5-HT produced a multiphasic mortality curve: small doses increased mortality significantly above controls, mortality then fell to near-control levels as dose increased, and at a critical dose it rose again considerably above controls. Intravenous injection of 5-HT, LSD, or BOL at the doses used caused no significant difference in mortality compared to controls. However, an equimolar intravenous combination of 5-HT and LSD significantly increased mortality after trauma compared to 5-HT plus BOL or saline.