Psychedelic interventions for major depressive disorder in the elderly: Exploring novel therapies, promise and potential.
Dialogues in clinical neuroscience December 1, 2025 Ivona-Maria Tudorancea, Gabriela-Dumitrita Stanciu, Carla Torrent et al. 4 citations
As the global population ages, depression in older adults is increasingly common, yet conventional antidepressants often have limited effectiveness and problematic side effects. Psychedelic compounds are emerging as a potential alternative. This review examines preclinical and clinical evidence suggesting psychedelics could treat major depressive disorder in the elderly. It discusses the neurobiological mechanisms behind these effects, highlights relevant animal models, and addresses safety concerns. The authors propose strategies to improve the efficacy and safety of psychedelic therapy in future clinical trials, offering a new avenue for treating late-life depression.