Increased signal diversity/complexity of spontaneous EEG, but not evoked EEG responses, in ketamine-induced psychedelic state in humans.
PLoS One November 23, 2020 Nadine Farnes, Bjørn E. Juel, André S. Nilsen et al. 81 citations
In humans, the psychedelic state induced by ketamine is associated with increased diversity and complexity of spontaneous electroencephalography (EEG) signals, but not of evoked EEG responses. This suggests that ketamine's effects on brain dynamics are specific to ongoing, internally generated neural activity rather than to stimulus-driven responses. The finding points to a potential neural marker of altered consciousness under psychedelics.