The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China; The State Key Lab of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China. Electronic address: chenhui@zju.edu.cn.
2 papers in the library · 8 citations · publishing 2024-2025
Ketamine, a common anesthetic for children, can harm the developing brain by triggering two forms of cell death: ferroptosis and pyroptosis. In experiments on newborn rats and cultured nerve cells, giving N-acetylcysteine (NAC) beforehand reduced damage. NAC lowered harmful lipid oxidation and mitochondrial injury, blocked pyroptosis driven by the NLRP3/caspase-1 pathway, and lessened hippocampal tissue damage and later cognitive problems. The results indicate that reactive oxygen species (ROS) are central to ketamine's developmental neurotoxicity, and NAC protects the brain by inhibiting ROS-driven ferroptosis and pyroptosis.
Facing pairs of human heads gain privileged access to conscious awareness compared to nonfacing pairs, even when presented outside awareness. Eleven experiments using a breaking continuous flash suppression paradigm showed that two human faces facing each other broke into awareness faster than nonfacing pairs. This advantage could not be explained by low-level or mid-level visual features. Disrupting holistic processing of the two agents significantly reduced the facing advantage. The effect was specific to human agents and did not occur with daily objects, directional arrows, or nonhuman animals. These results suggest that social information, specifically the facingness between two individuals, can be integrated unconsciously and influences what reaches conscious awareness.