Serious adverse events in psychedelic-assisted therapy trials can arise from interactions between therapists and patients. This Viewpoint discusses such events, highlighting the importance of therapeutic relationship dynamics in ensuring participant safety.
The Canadian Psychological Association Code of Ethics provides a framework that can support ethical decision-making in psychedelic-assisted psychotherapy, but its application requires careful consideration of unique challenges such as managing altered states of consciousness, ensuring informed consent, and addressing boundary issues. The code's principles of respect for dignity, responsible caring, integrity, and social responsibility offer guidance, yet the novel therapeutic context demands additional ethical reflection and potential adaptations to maintain professional standards.