THC, CBD and minor cannabinoid CBDV differently modulate hippocampal neurons firing.
Neurotoxicology May 1, 2025 Giulia Tomagra, Nikita Gandlevskiy, Elena Rosso et al. 3 citations
Cannabis sativa contains many minor cannabinoids beyond THC and CBD, and their effects on neuronal activity are not fully understood. In cultured hippocampal neurons, standard THC alone or combined with CBD significantly reduced spontaneous firing and burst generation, while CBD alone had no effect. Extracts from Cannabis sativa showed that cannabidivarin (CBDV), a non-psychoactive cannabinoid, reversed the inhibition of firing caused by the THC-CBD mixture. When applied alone, CBDV increased neuronal firing. All effects returned to baseline within 24 hours. These results suggest CBDV can counteract the suppressive effect of THC and CBD on neuronal activity.