Prediction of hallucinogen persisting perception disorder and thought disturbance symptoms following psychedelic use.
PNAS nexus April 1, 2025 Katie Zhou, David de Wied, Robin L Carhart-Harris et al. 9 citations
Delusional ideation decreased one month after a planned psychedelic experience, while magical thinking showed no change. Over 30% of participants reported hallucinogen persisting perception disorder (HPPD)-type effects at four weeks, though fewer than 1% found them distressing. Younger age, female gender, a history of psychiatric diagnosis, and baseline trait absorption predicted HPPD-like effects. Lifetime psychedelic use at baseline correlated positively with both magical thinking and delusional ideation, suggesting these traits may correlate with psychedelic use rather than being caused by it.