Low doses of LSD reduce broadband oscillatory power and modulate event-related potentials in healthy adults
Psychopharmacology October 6, 2021 Conor H. Murray, Ilaria Tare, Claire Perry et al. 75 citations
Low doses of LSD (13 and 26 micrograms) produced broad reductions in brain wave power across multiple frequency bands during rest and dampened specific event-related potentials (P300 and N170) during a visual task in healthy adults. The drug also increased positive mood, energy, and anxiety, as well as heart rate and blood pressure, but did not cause the full perceptual or sensory changes typical of higher psychedelic doses. These neurophysiological effects resemble those seen with higher doses, suggesting that very low LSD doses might produce subtle behavioral or therapeutic effects without inducing a full psychedelic experience.