Altered network hub connectivity after acute LSD administration
NeuroImage: Clinical March 7, 2018 F. Müller, P. Dolder, A. Schmidt et al. 187 citations
LSD alters brain network connectivity. In a double-blind, randomized, crossover study, 20 healthy participants received 100 μg LSD or placebo, and resting-state brain activity was measured with fMRI. LSD decreased functional connectivity within visual, sensorimotor, auditory, and default mode networks, while increasing connectivity between networks and subcortical (thalamus, striatum) and cortical (precuneus, anterior cingulate cortex) hub structures. These hub changes resemble patterns seen in psychosis and may relate to therapeutic effects of hallucinogens.