HHC-induced psychosis in adolescents: a case series
Irish Journal of Psychological Medicine June 19, 2026 Piril Cevikel, Joana Ferreira, Eamon Raji et al.
Two adolescents with no prior psychiatric history developed psychosis after using the semi-synthetic cannabinoid hexahydrocannabinol (HHC), requiring about six weeks of inpatient psychiatric treatment. Their symptoms resolved following abstinence from HHC and treatment with antipsychotic medications. These cases support recent regulatory measures banning HHC and highlight the need for clinician awareness of its associated risk of psychosis.