N,N-dimethyltryptamine Prevents Renal Ischemia-Reperfusion Injury in a Rat Model.
Transplantation Proceedings May 1, 2019 B. Nemes, K. Peto, N. Németh et al. 21 citations
In a rat model of kidney ischemia-reperfusion injury, the psychedelic compound N,N-dimethyltryptamine (DMT) given before ischemia improved recovery of microcirculation and reduced tissue damage. Microcirculation dropped in all groups, but the DMT-treated group recovered better after 30 minutes of reperfusion and had similar blood flow to the control group after 120 minutes, while the untreated ischemia group had higher flow. Tubular necrosis occurred in both ischemia groups but was moderate with DMT and severe without. Histologic injuries were less in the DMT group. The findings suggest DMT may protect kidneys during transplantation.