Thin-Layer Chromatography Method for the Detection of N,N-Dimethyltryptamine in Seized Street Samples
Jpc-journal of Planar Chromatography-modern Tlc November 17, 2014 B. Duffau, Sonia Rojas, S. Jofre et al. 6 citations
Dimethyltryptamine (DMT) is an endogenous hallucinogen traditionally used in the orally active preparation Ayahuasca by indigenous Amazonian communities. Recreational DMT use is increasing worldwide, with smoking being the most prevalent route of administration. DMT dose-dependently elevates blood pressure, heart rate, pupil diameter, rectal temperature, and blood concentrations of beta-endorphin, corticotrophins, cortisol, and prolactin; growth hormone levels rise equally across doses, while melatonin remains unaffected. Little information exists on DMT in street samples. A fast, reliable, low-cost method using high-performance thin-layer chromatography (HPTLC) was developed and validated for detecting and quantifying DMT in illicit powder samples, with uncertainty also evaluated.