Computational Psychiatry Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich 8032, Switzerland; University of Bonn, Transdisciplinary Research Area "Life and Health", Centre for Artificial Intelligence and Neuroscience, Bonn 53121, Germany; Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London WC1B 5EH, United Kingdom. Electronic address: d.bach@uni-bonn.de.
A systematic review of 100 publications found that 36 pharmacological compounds have been tested for their effects on aversive memory in healthy humans. The most studied drugs were hydrocortisone, propranolol, and D-cycloserine. Solid evidence supports propranolol's impact on memory reconsolidation, while weak evidence suggests effects of several compounds on memory encoding, consolidation, or extinction. Fifteen compounds showed significant effects in single studies without replication. The review highlights the need for greater comparability across studies.