Chronic ketamine use associated with progressive multisystem organ dysfunction.
BMJ case reports July 8, 2026 Cocoa Mudgal, H J Bodansky
Chronic heavy ketamine use over 15 years in a man in his 30s led to progressive failure of multiple organ systems, including bladder inflammation (ketamine cystitis), bile duct damage (cholangiopathy), urinary tract obstruction, heart muscle disease (cardiomyopathy), and mood disorder. The case demonstrates that long-term ketamine misuse can cause cumulative, widespread toxicity affecting many parts of the body.