A Single Ketamine Infusion Combined With Motivational Enhancement Therapy for Alcohol Use Disorder: A Randomized Midazolam-Controlled Pilot Trial.
American Journal of Psychiatry December 2, 2019 E. Dakwar, F. Levin, C. Hart et al. 179 citations
A single low-dose ketamine infusion, combined with motivational enhancement therapy, increased the likelihood of abstinence and reduced heavy drinking days in adults with alcohol dependence. In a pilot study, 40 participants received either ketamine or the active control midazolam. Ketamine delayed relapse and was well tolerated, with no dropouts due to adverse events. The results suggest a potential new approach integrating pharmacotherapy with behavioral treatment, though larger studies are needed to confirm these findings.