A Single Ketamine Infusion Combined With Mindfulness-Based Behavioral Modification to Treat Cocaine Dependence: A Randomized Clinical Trial.
American Journal of Psychiatry June 24, 2019 E. Dakwar, E. Nunes, C. Hart et al. 179 citations
A single infusion of ketamine, combined with mindfulness-based relapse prevention, helped adults dependent on cocaine stay abstinent longer and reduce cravings. In a trial with 55 participants, 48.2% of those receiving ketamine maintained abstinence over the final two weeks, compared to 10.7% in the control group receiving midazolam. The ketamine group was 53% less likely to relapse or drop out, and their craving scores were 58.1% lower throughout the study. The infusions were well tolerated with no serious adverse events. The authors suggest these results are promising but need replication in a larger sample.