Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments
Proceedings of the National Academy of Sciences of the United States of America November 27, 2023 J. Krystal, Alfred P. Kaye, S. Jefferson et al. 66 citations
Ketamine represents a new type of antidepressant that works quickly, helps people whose depression has not responded to other treatments, and reduces the chance of relapse. Its development came from a new understanding of depression's biology, and studying how ketamine works has deepened knowledge of depression and related conditions. Twenty-five years after the first findings on ketamine for depression were presented, this review examines what has been learned and suggests future ways to improve rapid-acting antidepressant therapy.