Pharmacodynamic Interactions Between Ketamine and Psychiatric Medications Used in the Treatment of Depression: A Systematic Review
International Journal of Neuropsychopharmacology June 25, 2021 J. Veraart, S. Smith-Apeldoorn, I. M. Bakker et al. 44 citations
Benzodiazepines and possibly lamotrigine reduce the antidepressant effects of ketamine, while lithium shows no significant interaction. Evidence from 24 studies indicates that clozapine, haloperidol, and risperidone interact with ketamine, though findings are mixed and based on low-quality evidence due to small sample sizes and varied methods. The review highlights the need for caution when combining ketamine with these drugs in psychiatric treatment.