Intranasal esketamine use in treatment-resistant depression: mechanism of action, clinical adverse effects, contraindications, safe administration protocol and treatment process
Academic Journal of Neuropsychiatry and Neuropsychology June 27, 2026 Abdullah Burak Uygur, Kadir Karakuş, Selime Çelik Erden et al.
Esketamine, a novel treatment for depression, works through NMDA receptors and intracellular signaling pathways, moving beyond traditional monoamine-based antidepressants. The article reviews its mechanism of action, clinical adverse effects, contraindications, safe administration protocols, and treatment process. Esketamine offers a rapidly acting option for depression, but its use requires careful management due to potential adverse effects and specific contraindications.