Hippocampal subfield volumes in treatment resistant depression and serial ketamine treatment
Frontiers in Psychiatry October 9, 2023 A. Zavaliangos-Petropulu, Shawn M. Mcclintock, S. Joshi et al. 6 citations
In patients with treatment-resistant depression, smaller hippocampal subfield volumes (left CA4 and GC-ML-DG) were observed before ketamine treatment compared to healthy controls. Four ketamine infusions over two weeks did not change hippocampal subfield volumes, and pre-treatment volumes did not predict improvement in depressive symptoms. However, smaller pre-treatment left CA4 and GC-ML-DG volumes were associated with greater improvement in processing speed after ketamine, and larger right CA3 volume was linked to better working memory at follow-up. Baseline hippocampal subfield volumes may serve as biomarkers for cognitive, but not antidepressant, response to ketamine.