Characterizing brain dynamics during ketamine-induced dissociation and subsequent interactions with propofol using human intracranial neurophysiology
Nature Communications March 29, 2023 Fangyun Tian, Laura D. Lewis, David W. Zhou et al. 63 citations
Ketamine produces different brain oscillations in distinct regions: gamma oscillations in prefrontal cortex and hippocampus, linked to antidepressant effects, and a 3 Hz oscillation in posteromedial cortex, linked to dissociative effects. By analyzing intracranial recordings from humans and comparing effects with propofol, the authors identified that these frequency-dependent patterns arise from distinct neural circuits, potentially guiding development of biomarkers and treatments for depression.