Evaluation of Sensorimotor Gating Deficits in Mice Through Prepulse Inhibition (PPI) of the Startle Response.
Methods in molecular biology (Clifton, N.J.) January 1, 2023 Paula Unzueta-Larrinaga, Leyre Urigüen 1 citation
Prepulse inhibition of the startle response is a behavioral measure used to study sensorimotor gating deficits seen in schizophrenia. Hallucinogenic drugs that activate 5-HT2A receptors, such as psilocybin, LSD, and DOI, produce schizophrenia-like symptoms in healthy people and can model these behaviors in rodents. This protocol describes how to evaluate prepulse inhibition in male CD1-Swiss mice after a single dose of DOI.