Evaluation of potential punishing effects of 2,5-dimethoxy-4-methylamphetamine (DOM) in rhesus monkeys responding under a choice procedure.
Behavioural pharmacology October 1, 2024 David R Maguire 2 citations
A 5-HT2A receptor agonist called DOM, tested in four rhesus monkeys using a choice procedure, showed neither rewarding nor punishing effects. When monkeys chose between a sucrose pellet alone or a pellet plus an intravenous infusion, fentanyl increased choice for the infusion (rewarding), while histamine decreased it (punishing). DOM, tested across doses of 3.2 to 100 µg/kg/infusion, did not systematically alter choice, whether given before or after histamine. This suggests DOM lacks both positive reinforcing and aversive properties under conditions sensitive to these effects.