Comparison of the action of lysergic acid diethylamide and apomorphine on the copulatory response in the female rat
Psychopharmacology January 1, 1976 Mona Eliasson, Bengt J. Meyerson 34 citations
Lysergic acid diethylamide (LSD) and apomorphine both inhibited lordosis behavior in ovariectomized estrogen- and progesterone-treated rats in a dose-dependent manner with similar time courses. Pimozide blocked the apomorphine-induced decrease but only partially reduced the LSD-induced inhibition. Chlorpromazine had a similar effect on LSD inhibition. The predominant action of LSD on female copulatory behavior is not mediated by increased dopamine receptor activity; instead, the LSD effect might be modulated by decreased dopaminergic activity.