Tabernanthalog Reduces Motivation for Heroin and Alcohol in a Polydrug Use Model.
Psychedelic medicine (New Rochelle, N.Y.) June 1, 2023 Jasper A Heinsbroek, Giuseppe Giannotti, Joel Bonilla et al. 26 citations
Tabernanthalog (TBG), a novel analogue of ibogaine and 5-methoxy-N,N-dimethyltryptamine, lacks classical psychedelic effects and cardiac arrhythmogenic risk. In a polydrug model of heroin and alcohol co-use in rats, TBG reduced motivation for both substances in a progressive ratio test, where the number of lever presses required for a reward increased exponentially. The study used a two-bottle binge protocol for alcohol exposure, followed by self-administration training for intravenous heroin or oral alcohol, and then sessions with both substances. TBG's efficacy was preserved in animals with a history of heroin and alcohol polydrug use.