A Case of 3,4-Dimethoxyamphetamine (3,4-DMA) and 3,4-Methylenedioxymethamphetamine (MDMA) Toxicity with Possible Metabolic Interaction.
Journal of psychoactive drugs January 1, 2016 Michael A Darracq, Stephen L Thornton, Alicia B Minns et al. 2 citations
A 19-year-old woman had two seizures and dangerously low sodium after taking "ecstasy" at a rave. Laboratory analysis of her blood and urine showed she had taken both MDMA and 3,4-DMA, and that her body produced very low levels of MDMA's CYP2D6 metabolites, indicating impaired metabolism through that pathway. The case suggests that combining MDMA with 3,4-DMA can lead to severe toxicity, including hyponatremia and seizures. Healthcare providers should be aware that people using illicit drugs may take multiple substances, and that such combinations can cause serious harm.