“Biosynthesis of psilocybin and its nonnatural derivatives by a promiscuous psilocybin synthesis pathway in Escherichia coli”
Biotechnology and Bioengineering June 20, 2023 Jessica E Flower, William J Gibbons, Alexandra M Adams et al. 26 citations
Bacterial production of psilocybin and 13 related compounds was achieved by adding the enzyme PsiH to the existing biosynthesis pathway. Testing 49 different indole derivatives revealed that the pathway enzymes accept many substrates, enabling the creation of a library of new drug candidates for mental health treatment.