Current Biology
February 20, 2016
Raphael Kaplan, Mohit H. Adhikari, Rikkert Hindriks et al.
127 citations
Hippocampal sharp-wave ripples, brief high-frequency oscillations linked to memory consolidation, are followed by a dramatic increase in fMRI signal within the default mode network (DMN) of anesthetized monkeys. This effect was specific to ripples and did not occur after other hippocampal events or in other resting-state networks. The findings link circuit-level neural dynamics—ripples—to network-level fluctuations in the DMN, providing mechanistic support for the DMN's role in memory consolidation.
NeuroImage
November 1, 2020
Gerald J. Hahn, Gorka Zamora‐lópez, Lynn Uhrig et al.
55 citations
Brain-wide signal levels can reliably distinguish sleep and anesthesia from the awake state in human and monkey fMRI resting state data. A whole-brain computational model reproduces changes in global synchronization, functional connectivity, structure-function relationship, integration, and segregation across vigilance states. The awake brain operates near a Hopf bifurcation, which coincides with globally correlated fMRI signals. Simulated lesions of connectivity hubs in the posterior brain and subcortical nuclei disrupt the model's awake state, matching predictions from graph-theoretical analyses of structural data.
bioRxiv Preprint Server
October 31, 2025
Tomas Hampejs, David Tomecek, Stanislav Jiricek et al.
preprint
Spontaneous, naturally occurring thoughts have distinct brain signatures that can be detected with combined fMRI and EEG recordings. Using machine learning on 240 samples from eight participants, internally versus externally oriented experiences were distinguished with 65.4% accuracy by fMRI and 62.5% by EEG. Externally oriented states involved greater activity in salience, auditory, and visuospatial brain networks and lower occipital alpha power, while internally oriented states showed the opposite pattern, extending prior accounts focused on the default mode network. Across modalities, alpha power correlated negatively with BOLD fluctuations in parietal and occipital regions, indicating that coordinated large-scale network dynamics and alpha oscillations track the natural alternation between inward and outward focus.