The combined effects of 3,4-methylenedioxymethamphetamine (MDMA) and selected substituted methcathinones on measures of neurotoxicity
Neurotoxicology and Teratology February 16, 2017 N. Miner, J. O'Callaghan, T. Phillips et al. 25 citations
Mice given MDMA alone at a high dose showed temporary decreases in dopamine and tyrosine hydroxylase in the striatum and an increase in a marker of astrocyte activation (GFAP). When the methcathinones methylone or MDPV were combined with a lower MDMA dose, they did not affect dopamine or tyrosine hydroxylase levels but blocked the MDMA-induced increase in GFAP. Seven days after treatment, all measures returned to normal, indicating the changes were transient. Most drug groups caused an initial drop in body temperature followed by a gradual rise, but MDPV did not produce this pattern, suggesting it affects thermoregulation differently.