Systems-level analysis of local field potentials reveals differential effects of lysergic acid diethylamide and ketamine on neuronal activity and functional connectivity.
Frontiers in neuroscience January 1, 2023 Azat Nasretdinov, Sebastian A Barrientos, Ivani Brys et al. 6 citations
LSD and ketamine produce altered brain states through different underlying mechanisms. In rodents, ketamine increased neuronal activity (indicated by shifts in local field potential power) but reduced connectivity between brain structures, while LSD also reduced connectivity but without a change in broadband power. The findings help bridge human imaging studies, which show altered functional connectivity, with invasive animal recordings that reveal high-frequency oscillations. Understanding these distinct neurophysiological signatures may clarify how classic psychedelics and dissociative anesthetics affect the brain, informing their potential therapeutic uses for psychiatric conditions.