The thalamus in psychosis spectrum disorder.
Frontiers in neuroscience January 1, 2023 Alan Anticevic, Michael M. Halassa 41 citations
Psychosis spectrum disorder affects 1% of the world population and leads to chronic disability. Developing treatments for its cognitive deficits is hindered by a weak link between neurobiological understanding and clinical symptoms. This perspective highlights an opportunity combining non-invasive human neuroimaging with insights into thalamic regulation of cortical connectivity. The thalamus forms forebrain-wide functional loops critical for processing external inputs and updating internal models. Evidence shows PSD symptomatology may stem from faulty network organization with the thalamus as a central coordinator. Animal work clarifies thalamic circuits regulating cortical dynamics and cognition.