Effects of noribogaine on the development of tolerance to antinociceptive action of morphine in mice.
Brain research October 17, 1997 Hemendra N Bhargava, Ying-Jun Cao 10 citations
Noribogaine, a metabolite of ibogaine, reduced the development of tolerance to morphine's pain-relieving effect in male Swiss-Webster mice. Tolerance was induced by implanting a 25 mg morphine pellet for 4 days or by injecting morphine (20 mg/kg) twice daily for 4 days. In pellet-implanted mice, 20 mg/kg of noribogaine attenuated tolerance, while lower doses had no effect. In mice receiving multiple injections, 20 and 40 mg/kg doses also attenuated tolerance. Since noribogaine worked at lower doses than ibogaine (which required 40–80 mg/kg in previous work), the authors suggest ibogaine's effect may depend on its conversion to the more active noribogaine.