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David John Nutt

3 papers in the library · 135 citations · publishing 2013-2024

Papers

Antidepressant effects of a psychedelic experience in a large prospective naturalistic sample.

J Psychopharmacol August 1, 2022 Victoria Amalie Nygart, Lis Marie Pommerencke, Eline Haijen et al. 73 citations

Depressive symptoms decreased two and four weeks after a psychedelic experience in a naturalistic, non-clinical setting. The study tracked a large group of people who planned to use psychedelics outside a lab or clinic, including only those with depressive symptoms at the start. A medicinal motive, prior psychedelic use, drug dose, and having an emotional breakthrough during the experience were all linked to greater symptom reductions. The authors note potential sample and attrition biases and call for further controlled and observational studies to confirm the findings.

Experienced Drug Users Assess the Relative Harms and Benefits of Drugs: A Web-Based Survey

Journal of Psychoactive Drugs September 1, 2013 Robin Lester Carhart-Harris, David John Nutt 55 citations

Experienced drug users who have personally used 11 different illicit drugs rank alcohol and tobacco as the most harmful substances, while MDMA, LSD, psilocybin, and cannabis are ranked as the four least harmful. When asked about potential benefits, these same four drugs are ranked highest, and users cite therapeutic applications—such as tools to assist psychotherapy—rather than just pleasure. The findings offer insight from a rare sample of 93 users with intimate knowledge of multiple drugs.

Feasibility of a cannabidiol-dominant cannabis-based medicinal product for the treatment of long COVID symptoms: A single-arm open-label feasibility trial.

Br J Clin Pharmacol January 17, 2024 Hannah Thurgur, Michael Lynskey, Anne Katrin Schlag et al. 7 citations

Lingering long COVID symptoms often severely impact daily life. A trial explored if a cannabidiol-dominant product offers a viable treatment. Participants experienced encouraging improvements in issues like pain, sleep, fatigue, and anxiety. This suggests a promising way to alleviate these symptoms and significantly boost overall quality of life for those affected by long COVID.