Reconsidering evidence for psychedelic-induced psychosis: An overview of reviews, a systematic review, and meta-analysis of human studies
European Psychiatry April 1, 2025 M. Sabé 3 citations
Among people without a history of psychotic symptoms, psychedelic-induced psychosis is very rare: 0.002% in population studies, 0.2% in uncontrolled trials, and 0.6% in randomized controlled trials. In uncontrolled trials that included people with schizophrenia, 3.8% developed long-lasting psychotic symptoms. Among those who experienced psychedelic-induced psychosis, 13.1% later developed schizophrenia. The evidence suggests that schizophrenia may not be an absolute exclusion for psychedelic therapy trials, but the authors recommend a conservative approach due to low study quality and limited data.