A Single Dose of Lysergic Acid Diethylamide Influences Gene Expression Patterns within the Mammalian Brain
Neuropsychopharmacology May 1, 2002 C Nichols 165 citations
Lysergic acid diethylamide (LSD) produces profound effects such as hallucinations and detachment from reality, which resemble symptoms of schizophrenia. The first comprehensive analysis of gene expression after acute LSD administration in the mammalian brain identified genes involved in synaptic plasticity, glutamatergic signaling, and cytoskeletal architecture. These molecular events may provide new insights into disorders with similar behavioral symptoms and could lead to new therapies.