The utility of microdosing over the past 5 years
Expert Opinion on Drug Metabolism & Toxicology November 28, 2008 Graham Lappin, R Colin Garner 89 citations
A review of 18 drugs found that 15 showed linear pharmacokinetics, meaning their drug concentration profiles at a microdose (≤100 micrograms) fell within a factor of two of those at a therapeutic dose. This supports the use of microdosing in Phase 0 trials to predict how a drug will behave at clinically relevant doses, helping to select candidates for further testing.