Effects of psychedelics on neurogenesis and broader neuroplasticity: a systematic review.
Mol Med December 19, 2024 Rafael V. Lima da Cruz, Richardson N. Leão, Thiago C. Moulin 13 citations
New neurons continue to be generated in the mammalian brain throughout life, a process called adult neurogenesis that is linked to stress regulation and mood disorders. Psychedelic compounds—including phenethylamines, tryptamines, cannabinoids, and others—have emerged as potential treatments for neuropsychiatric disorders, with many reports connecting their effects to increased adult neurogenesis. This systematic review examined studies on neurogenesis and related brain plasticity after psychedelic interventions, searching PubMed and Science Direct for articles published up to January 31, 2023. The authors analyzed experimental studies using in vivo or in vitro models and human studies, categorizing findings into five psychedelic classes: CB1 agonists, NMDA antagonists, harmala alkaloids, tryptamines, and entactogens. The review describes how different psychedelics may affect the birth of new neurons and brain plasticity, offering insights for future therapeutic strategies.